CYP1A2 Totally Explained

Everything about Cyp1a2 totally explained

| Name = Cytochrome P450, family 1, subfamily A, polypeptide 2 | HGNCid = 2596 | Symbol = CYP1A2 | AltSymbols =; CP12; P3-450; P450(PA) | OMIM = 124060 | ECnumber = | Homologene = 68082 | MGIid = 88589 | GeneAtlas_image1 = PBB_GE_CYP1A2_207609_s_at_tn.png | GeneAtlas_image2 = PBB_GE_CYP1A2_207608_x_at_tn.png | Function = | Component = | Process = | Orthologs = }}
Cytochrome P450 1A2 (abbreviated CYP1A2), a member of the cytochrome P450 mixed-function oxidase system, is involved in the metabolism of xenobiotics in the body.
Expression of CYP1A2 appears to be induced by various dietary constituents.

CYP1A2 Ligands

Table of selected substrates, inducers and inhibitors of CYP1A2¹

Substrates	Inhibitors	Inducers
Often mentioned : some Antidepressants Amitriptyline (tricyclic antidepressant) Imipramine (antidepressant) Clomipramine (tricyclic antidepressant) Clozapine (atypical antipsychotic) Caffeine (stimulant) Olanzapine (atypical antipsychotic) Ropivacaine (local anaesthetic) Theophylline (Xanthine) Zolmitriptan (Serotonin receptor agonist) Other: cyclobenzaprine (muscle relaxant, depressant) estradiol (in hypoestrogenism) fluvoxamine (SSRI antidepressant) haloperidol (Typical antipsychotic) ondansetron (5-HT3 antagonist) mexiletine (Antiarrhythmic agent) Melatonin (antioxidant, sleep-inducer) Tamoxifen (SERM) naproxen (NSAID) paracetamol (analgesic, antipyretic) phenacetin (analgesic) propranolol (beta blocker) riluzole (in amyotrophic lateral sclerosis) tacrine (parasympathomimetic) tizanidine (α-2 adrenergic agonist) Verapamil (calcium channel blocker) warfarin (anticoagulant) zileuton (in asthma) lidocaine (local anesthetic, antiarrhythmic)	Ciprofloxacin (fluoroquinolone bactericidal) Many other fluoroquinolones (broad-spectrum antibiotics) Fluvoxamine (SSRI antidepressant) Verapamil (calcium channel blocker) unspecified: amiodarone (antiarrhythmic agent) cimetidine (H2-receptor antagonist) furafylline interferon (antiviral, antiseptic, antioncogenic) methoxsalen (in psoriasis) caffeine (stimulant) echinacea (Immunostimulator) enoxacin (antibacterial ) mexiletine (Antiarrhythmic agent) hormonal contraception zileuton (in asthma)	broccoli brussel sprouts chargrilled meat insulin (in diabetes) modafinil (eugeroic) nafcillin (beta-lactam antibiotic) omeprazole (proton pump inhibitor) hyperforin (constituent of St Johns Wort) (antidepressant) carbamazepine (anticonvulsant) phenobarbital (anticonvulsant) rifampicin (bactericidal)

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